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KMID : 0895820050150020117
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Journal of Oriental Rehabilitation Medicine
2005 Volume.15 No. 2 p.117 ~ p.139
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Anti-obesity Effects of SBY-Ⅲ in High Fat Diet-Fed Obese Rats Continued by High Fat Diet and Regulated by Normal Diet
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Woo Kyung-Ha
Chung Seok-Hee
Lee Jong-Soo
Kim Sung-Su
Shin Hyun-Dae
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Abstract
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Objectives: This experimental study was designed to investigate the effect of SBY-Ⅲ extract on the weight, cell size of epididymal fat-pad, fat accumulation area in liver, serum lipid level and UCP1 mRNA in brown adipose tissue of high fat diet-fed obese rats continued by high fat diet and regulated by normal Diet.
Methods: The body weight gain, weight of the internal organs(epididyrmis, liver, brown adipose tissue), insulin, triglyceride, total cholesterol, total lipid, free fatty acid, expression of UCP1 mRNA were measured in high fat diet-fed obese rats continued by high fat diet and regulated by normal diet. The experimental study are divided into exp-Ⅰand exp-Ⅱ. Each study was adminstered normal diet, high fat diet and SBY-Ⅲ according to each situation. Normal group is normal diet for 8 weeks. Exp-Ⅰ are divided into control group(high fat diet for 8 weeks) and sample group(high fat diet for 8 weeks and SBY-Ⅲ for last 2 weeks). Exp-Ⅱ are divived into control group(high fat diet for 6 weeks and normal diet for 2 weeks) and sample group(high fat diet for 6 weeks and normal diet with SBY-Ⅲ for 2 weeks). These were then compared mutually.
Results:
1. Irrespective of diet control, sample group taken SBY-Ⅲ showed the more effective decrease of weight gain than control group and diet control-fed sample group with SBY-Ⅲ showed the more effective decrease of weight loss including weight gain than control group.
2. Irrespective of diet control, sample group taken SBY-Ⅲ showed the more effective decrease cell size of epididymal fat-pad, fat accumulation area in liver than control group.
3. Non diet control-fed sample group taken SBY-Ⅲ showed the more effective decrease of serum triglyceride, total lipid, free fatty acid than control group and diet control-fed sample group taken SBY-Ⅲ showed the decrease of serum triglyceride, free fatty acid than control group.
4. Only diet control-fed sample group taken SBY-Ⅲ showed the decrease of UCP1 volume.
Conclusions: These results shows that SBY-Ⅲ has effects on anti-obesity, especially keeping pace with diet control.
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KEYWORD
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SBY-Ⅲ, Obesity, Diet control, High fat diet
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